Award details

The role of FMDV proteins in immune evasion

Reference	BBS/E/I/00001440
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	234,930
Status	Completed
Type	Institute Project
Start date	01/07/2009
End date	31/03/2012
Duration	33 months

Abstract

The mechanisms by which FMDV counteracts the host’s innate and adaptive immune responses and the role of viral proteins in this process are not well understood. It is known that the viral leader proteinase, Lpro, inhibits the induction of IFNa/ß and blocks host cell mRNA translation. In addition, 2B in conjunction with 2C or their precursor protein 2BC inhibits protein trafficking through the ER and Golgi. Disruption of the secretory pathway could result in a decrease in MHC class I molecules on the cell surface, which may delay virus clearance in vivo. This project will determine the effect of 2BC on cell surface expression of MHC class I and NK cell receptor ligands and will determine if 2BC adversely affects the secretion of immunomodulatory molecules. Apoptosis is an innate cellular response that can limit viral propagation and many viruses express proteins that block apoptosis. However, apoptosis might also facilitate virus dissemination and viral pro-apoptotic mechanisms have been described. In this project, the interaction of FMDV with cellular proteins involved in the control of apoptosis will also be undertaken.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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