Award details

Genetics and mechanisms of disease resistance in cattle involving major histocompatibility complex (MHC) genes

Reference	BBS/E/I/00001435
Principal Investigator / Supervisor	Professor Shirley Ellis
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	597,478
Status	Completed
Type	Institute Project
Start date	01/07/2009
End date	31/03/2012
Duration	33 months

Abstract

The project centres on genetic diversity present in families of genes involved in immune responses and disease resistance, and the related functional implications of this variation. We already have a good understanding of the complexities of the cattle MHC genes, although assessment of MHC diversity in different breeds and populations is on-going. These genes are centrally involved in both adaptive and innate immune responses, interacting with T cell receptors and natural killer (NK) cell receptors. Detailed analysis of NK cell receptor genes is essential to gain an understanding of the complex interplay of NK cells, receptors, their ligands and pathogens. Characterisation of these genes and their ligands is the main component of the project. This will give an insight to the functional implications of genetic variation and will lead on to further population-based studies. In addition to this work the project encompasses some MHC typing essential for maintenance and development of the IAH genetically defined cattle herd.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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