Award details

Molecular biology of foot-and-mouth disease virus:entry replication and assembly

Reference	BBS/E/I/00001411
Principal Investigator / Supervisor	Dr Tobias Tuthill
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	889,137
Status	Completed
Type	Institute Project
Start date	03/08/2009
End date	31/03/2014
Duration	56 months

Abstract

The proposed research aims to investigate the following key stages of the FMDV life cycle: i) Membrane penetration by using model membranes, ii) Capsid assembly by using fluorescent and structural approaches, iii) Genome replication and packaging by using cell culture & cell-free replication systems. Work will build upon the research findings, hypotheses, collaborations and techniques developed during nine years of picornavirus research at the University of Leeds. This work has involved viruses such as poliovirus (PV), human rhinovirus (HRV) and of particular relevance to this application, the aphthovirus equine rhinitis A virus (ERAV), the latter having been developed specifically as a surrogate model for FMDV. Substantial preliminary data exists for several aspects of this proposal which will expedite rapid progress in i) experimental work, ii) publication in peer reviewed journals and iii) the procurement of external funding with which to expand the program.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology, Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search