Award details

Marker vaccine potential of a partial VP1 deleted foot and mouth disease virus

Reference	BBS/E/I/00001407
Principal Investigator / Supervisor	Dr Paul Barnett
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	72,710
Status	Completed
Type	Institute Project
Start date	01/03/2009
End date	30/06/2010
Duration	16 months

Abstract

Foot-and-mouth disease (FMD) virus causes a highly infectious vesicular disease of cloven hoofed animals. Although mortality rates are generally low, outbreaks of FMD are economically devastating, illustrated by the UK 2001 outbreak (greater than 12Bn Euros). Control can be improved by the use of vaccination. However, current FMD vaccines have limitations, leading to reluctance of use, particularly in countries which are usually free from disease. One such limitation is the identification of persistently infected animals which is problematic using current technology. This problem could be overcome by the use of specifically engineered marker vaccines, however none are presently available. Using in vitro analysis of serum collected during a trial at IAH, we have discovered that a vaccine lacking the antigenic portion of the VP1 protein has potential as a marker vaccine for FMD. It was not possible to evaluate this hypothesis by challenge. However, serology was consistent with protection in cattle. The proposed project aims to evaluate this hypothesis by undertaking a vaccination/challenge study in cattle using a vaccine virus lacking an antigenic region of the VP1 protein.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search