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Award details
The molecular basis and impact on host responses of phenotypic variation across Mycobacterium bovis molecular types
Reference
BBS/E/I/00001339
Principal Investigator / Supervisor
Professor Tracey Coffey
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
53,200
Status
Completed
Type
Institute Project
Start date
10/12/2007
End date
09/12/2010
Duration
36 months
Abstract
Mycobacterium bovis is the Bovine Tuberculosis (bTB) is an endemic disease of the UK cattle population caused by. Molecular typing of M. bovis isolates shows the emergence of expanding clones of the pathogen, with comparative genomic, transcriptome, and metabolic fingerprinting studies showing that these clonal groups share characteristics. The success of these clones may therefore be down to their ability to modulate the host response to infection. The objectives of this proposal are therefore (1) to determine the impact of M. bovis molecular types on the innate immune responses in the bovine host (2) to identify the molecular basis in the pathogen for these differential responses.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Animal Health, Immunology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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