Award details

Virulent/avirulent strain comparison to detect pathogen and host factors critical to the pathogenesis of bovine mastitis due to S. uberis

Reference	BBS/E/I/00001338
Principal Investigator / Supervisor	Professor Tracey Coffey
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	107,566
Status	Completed
Type	Institute Project
Start date	07/04/2008
End date	06/04/2011
Duration	36 months

Abstract

The aim of the current proposal is to identify genes (and products) of S. uberis and the bovine host that play an essential role in disease pathogenesis that could be exploited in the future control of bovine mastitis. This will be achieved by fulfilling the following objectives: 1. Determine phenotypic and genotypic differences between defined virulent and avirulent strains of S. uberis; 2. Determine differences in the host response following challenge with defined virulent and avirulent strains of S. uberis; 3. Production and in vivo analysis of the virulence of mutants of S. uberis 0140J that carry mutations within genes encoding external products that differ in virulent and avirulent strains.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Animal Welfare, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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