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Influence of viral proteins of avian influenza virus on the innate immune response of birds

Reference	BBS/E/I/00001307
Principal Investigator / Supervisor	Dr Colin Butter
Co-Investigators / Co-Supervisors	Dr John Young
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	325,570
Status	Completed
Type	Institute Project
Start date	01/01/2007
End date	31/03/2010
Duration	39 months

Abstract

The objectives of this work package are to determine genetic-related differences in the susceptibility of chickens and other avian species to infection with HPAI, and relate these to specific components of the innate immune response. This will inform both breeding strategies for domestic poultry flocks and define parts of the immune system that are subverted by the virus when evolving to higher virulence in a particular species or when increasing in host range. Objectives are 1) to determine the differential susceptibility and resistance of inbred lines of chicken to infection with H5N1z, both in vivo and in vitro; 2) to determine the sequence and functionality of Mx genes in inbred lines of chicken; 3) to analyse the nature of the innate immune response in susceptible and resistant lines of chicken.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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