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Bovine B cell responses to FMDV

Reference	BBS/E/I/00001296
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,411,828
Status	Completed
Type	Institute Project
Start date	25/08/2005
End date	30/06/2009
Duration	46 months

Abstract

Studies of immune responses induced by FMDV and their role in immunity have focused largely on antibody. The finding that transfer of immune serum to susceptible calves immediately before challenge with FMDV conveys substantial protection supports the view that antibody responses play an important role in immunity. In parallel with our studies of the T cell response to FMDV funded by the BBSRC, we propose to develop assays to quantify specific memory and effector B cell populations in cattle after FMDV infection or vaccination. The capacity to stimulate and maintain memory B cell populations will be correlated with the sustainability of circulating neutralising antibody titres and protection. These assays are likely to be broadly applicable to studies of B cells responses in cattle. This programme of work will largely utilise samples from externally funded cattle experiments. In addition, the early innate cytokine response to viral infections has been shown recently to influence B cell function. The early innate responses to FMDV infection and vaccination will be described, to inform the design of in vitro assays to identify factors that influence B cells responses to FMDV.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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