Award details

Studies on avian infectious bronchitis virus to underpin the development of stable advanced vaccines for more effective sustained control

Reference	BBS/E/I/00001256
Principal Investigator / Supervisor	Professor Paul Britton
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	109,065
Status	Completed
Type	Institute Project
Start date	01/04/2006
End date	13/04/2010
Duration	48 months

Abstract

A report commissioned by Defra demonstrated that infectious bronchitis (IB) is not only a major cause of ill health amongst chickens, it is also responsible for more economic loss in the UK poultry industry than any other infectious disease. The current live vaccines that are used to partly control the disease are not genetically stable. We have a reverse genetic system, that enables us to make genetically stable modifications to the genome for vaccine development. Our previous research with this system has shown that IBV produces a number of proteins that are not essential for replication in vitro. Removal of the genes encoding these proteins might attenuate the pathogenicity of the virus. To test this hypothesis we need a pathogenic clone of IBV, our current clone being non-pathogenic. The major part of this project is a step-wise modification of our existing clone, introducing genes from a pathogenic strain to make chimaeras, followed by testing the pathogenicity of the chimaeras.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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