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Award details
Global assignment of the function of Salmonella genes in livestock
Reference
BBS/E/I/00001255
Principal Investigator / Supervisor
Professor Mark Stevens
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
316,653
Status
Completed
Type
Institute Project
Start date
01/10/2006
End date
31/12/2009
Duration
39 months
Abstract
The aim of this proposal is to determine the extent to which every non-essential gene of Salmonella enterica serovar Typhimurium is required for intestinal colonisation of chickens, pigs and calves.To achieve this we propose the following objectives: 1. Use pre-existing libraries of S. Typhimurium mutants generated using transposons designed for use in the new Transposon-Mediated Differential Hybridisation technology, in screens for colonisation of chickens, pigs and calves; 2. Derive an 'attenuation index' for each mutant in each host; 3. Confirm the role of selected genes by targeted mutagenesis and infection studies in target animals; 4. Define the basis of attenuation of selected mutants.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Animal Health, Microbial Food Safety, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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