Award details

Neonatal Vaccination

Reference	BBS/E/I/00001244
Principal Investigator / Supervisor	Professor Jayne Hope
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	663,883
Status	Completed
Type	Institute Project
Start date	01/10/2005
End date	31/03/2009
Duration	42 months

Abstract

This proposal will concentrate on optimising heterologous prime-boost approaches to improve BCG by (i) identifying vaccine subunit candidates that boost BCG-induced immunity in cattle using antigen mining techniques that we have developed in previous research contracts, and comparing the efficacy of these vaccines in mice and cattle; (ii) testing new adjuvant systems in combination with promising subunit vaccines in cattle; (iii) testing TB vaccines in cattle that are in phase 1 clinical trials in humans and (iv) continuing to utilise the close and effective network of collaborations that we have developed with the human TB vaccine community. We have also engaged in a private/public partnership with a pharmaceutical company (Pfizer Animal Health), and this relationship will be developed over the life of this proposal. In addition, this proposal will support the continued development of reagents for differential diagnosis that are suitable for use in vaccinated animals.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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