Award details

Neonatal Vaccination

ReferenceBBS/E/I/00001244
Principal Investigator / Supervisor Professor Jayne Hope
Co-Investigators /
Co-Supervisors
Institution The Pirbright Institute
DepartmentThe Pirbright Institute Department
Funding typeResearch
Value (£) 663,883
StatusCompleted
TypeInstitute Project
Start date 01/10/2005
End date 31/03/2009
Duration42 months

Abstract

This proposal will concentrate on optimising heterologous prime-boost approaches to improve BCG by (i) identifying vaccine subunit candidates that boost BCG-induced immunity in cattle using antigen mining techniques that we have developed in previous research contracts, and comparing the efficacy of these vaccines in mice and cattle; (ii) testing new adjuvant systems in combination with promising subunit vaccines in cattle; (iii) testing TB vaccines in cattle that are in phase 1 clinical trials in humans and (iv) continuing to utilise the close and effective network of collaborations that we have developed with the human TB vaccine community. We have also engaged in a private/public partnership with a pharmaceutical company (Pfizer Animal Health), and this relationship will be developed over the life of this proposal. In addition, this proposal will support the continued development of reagents for differential diagnosis that are suitable for use in vaccinated animals.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsAnimal Health, Immunology
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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