BBSRC Portfolio Analyser
Award details
Vaccines developed as part of the human TB vaccine research effort
Reference
BBS/E/I/00001243
Principal Investigator / Supervisor
Professor Bernardo Villarreal-Ramos
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
318,503
Status
Completed
Type
Institute Project
Start date
01/10/2005
End date
31/03/2009
Duration
42 months
Abstract
The aim of this project is to optimise the heterologous prime-boost approaches to improve BCG by (i) identifying vaccine subunit candidates that boost BCG-induced immunity in cattle using antigen mining techniques that we have developed in previous research contracts, and comparing the efficacy of these vaccines in mice and cattle; (ii) testing new adjuvant systems in combination with promising subunit vaccines in cattle; (iii) testing TB vaccines in cattle that are in phase I clinical trials in humans, and (iv) continuing to utilise the close and effective network of collaborations that we have developed with the human TB vaccine community. We have also engaged in a private/public partnership with a pharmaceutical company (Pfizer Animal Health), and this relationship will be developed over the life of this proposal. In addition, this proposal will support the continued development of reagents for differential diagnosis that are suitable for use in vaccinated animals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Animal Health, Immunology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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