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Identification of genetic variation in innate immune response genes associated with resistance to chicken viral infections

Reference	BBS/E/I/00001242
Principal Investigator / Supervisor	Professor Peter Kaiser
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	215,367
Status	Completed
Type	Institute Project
Start date	01/06/2006
End date	31/08/2009
Duration	39 months

Abstract

The overall aim is to detect and associate differences (coding and gene expression polymorphisms) within innate immune responsive genes with disease resistance of inbred lines of chickens to infection from both DNA and RNA viruses. Specific Objectives: 1) to define chicken genes and pathways that respond to viral challenge; 2) to define intron/exons, coding and promoter regions of viral response genes; 3) to define phylogenetic relationship of avian and mammalian viral response genes ; 4) to estimate dN/dS ratios for viral response genes and relate to structure/function ; 5) to define a chicken viral response gene set ; 6) to identify promoter/coding sequence polymorphisms between inbred lines ; 7) to associate polymorphisms with disease resistance in inbred lines ; 8) to identify structure/function relationships of polymorphic sites within proteins ; 9) to verify candidate promoter polymorphisms.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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