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Inhibition of bacterial Type III secretion by salicylanilides
Reference
BBS/E/I/00001241
Principal Investigator / Supervisor
Professor Mark Stevens
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
171,398
Status
Completed
Type
Institute Project
Start date
12/10/2006
End date
11/04/2010
Duration
42 months
Abstract
The objectives of this study are: 1. To investigate the molecular mechanisms underlying inhibition of Salmonella TTSS-1 by salicylanilides; 2. To employ salicylanilides as molecular probes in a chemical genetic approach to study the importance of TTSS-mediated secretion in bacterial pathogenesis; 3. To evaluate if the inhibitory effect of salicylanilides could be alleviated by mutational inactivation of Salmonella gene(s); 4. To assess the potential for ;use of salicylanilides as novel broad spectrum anti-bacterial infection agents.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Animal Health, Microbial Food Safety, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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