Award details

Expression and formulation of Bluetongue virus genes and proteins for development of effective vaccination strategies

Reference	BBS/E/I/00001240
Principal Investigator / Supervisor	Professor Peter Mertens
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	235,172
Status	Completed
Type	Institute Project
Start date	01/06/2006
End date	04/12/2010
Duration	54 months

Abstract

The overall project objectives are to: 1. Generate cDNA copies of BTV genome segments 2, 3, 6 and 7 from current European strains; 2. Clone BTV ORFs, for expression of BTV proteins VP2, VP3, VP5 and VP7; 3. Generation of recombinant vaccinia virus to express BTV outer capsid proteins; 4. Expression and development of purification methods for BTV proteins; 5. Assess the antibody response to expressed BTV proteins; 6. Determine the cleavage products of VP2 present in BTV infectious subviral particles; 7. Development of particulate carrier vaccines based on single or multiple recombinant BTV proteins; 8. Development of a non-viral DNA vaccine strategy for BTV; 9. Evaluation of combined protein/DNA vaccine immunisation strategies towards the development of single-dose vaccines; 10. Protect any intellectual property generated by the project to help ensure commercialisation and use of any viable vaccination strategies/reagents.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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