BBSRC Portfolio Analyser
Award details
Investigating the role of follicular dendritc cells in TSE agent neuroinvasion from lymphoid tissues
Reference
BBS/E/I/00001238
Principal Investigator / Supervisor
Professor Neil Mabbott
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
12,418
Status
Completed
Type
Institute Project
Start date
01/09/2006
End date
31/08/2009
Duration
36 months
Abstract
The key objectives of the research described in this project are to determine the following: 1. Do follicular dendritc cells (FDCs) themselves actually express the cellular form of the prion protein, PrPc, or do they acquire it from other non-bone marrow-derived cells such as endothelial cells, muscle cells or neurons? 2. Do FDCs themselves replicate TSE agents, or do they accumulate them following replication by other cells? 3. Does efficient neuroinvasion by TSE agents require transmission from multiple lymphoid tissues, or can this occur from just the draining lymphoid tissue?
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Animal Health, Immunology, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search