Award details

CTL priming and the induction of CTL memory in virus infection in cattle

Reference	BBS/E/I/00001233
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	647,598
Status	Completed
Type	Institute Project
Start date	14/11/2005
End date	30/06/2009
Duration	43 months

Abstract

CD8+ T cells play a crucial role in recovery from virus infection and little is known about how factors that influence CTL priming and the induction of CTL memory in influence the outcome of virus infection in cattle. CD8+ T cell responses tend to be focussed on a limited number of dominant epitopes in individual animals. Consequently the response of different animals may be directed towards different proteins. Therefore, it is important to determine the extent to which bovine MHC influences the antigenic specificity of CD8+ T cell responses. This project will utilise bovine respiratory syncytial virus (BRSV) as a model of an acute virus infection of cattle, in which CD8+ T cells are known to be important in controlling infection, to determine the influence of bovine MHC class I genotype on viral protein and epitope recognition by bovine CD8+ T cells and to investigate factors that influence the generation and long-term survival of virus-specific CD8+ T cell memory. These studies will enable the development of methodologies for the qualitative and quantitative analysis of bovine CD8+ T cell memory that will help to ensure that potential vaccines induce qualitatively appropriate CTL responses. Furthermore, knowledge of factors that regulate the generation and long-term survival of memory CD8+ T cells in cattle will lead to the development of vaccines that incorporate appropriate antigens, cytokines or adjuvants that will induce long-term memory CD8+ T cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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