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Early events in scrapie pathogenesis: the role of phagocytic cells in scrapie susceptible and resistant sheep
Reference
BBS/E/I/00001229
Principal Investigator / Supervisor
Dr Eleanor Fiona Houston
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
11,459
Status
Completed
Type
Institute Project
Start date
01/11/2006
End date
31/10/2009
Duration
36 months
Abstract
The objectives of the project are: 1) To compare the relative abilities of phagocytic cells isolated from scrape susceptible and resistant sheep to take up and degrade PrPSc in vitro. 2) To verify the relevance of in vitro observations by determining which cell types in afferent lymph draining the site of inoculation have taken up PrPSc following experimental infection of susceptible and resistant sheep. 3) To compare the initial localisation and persistence of PrPSc in the drainage lymph nodes of susceptible and resistant sheep.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Animal Health, Immunology, TSEs (transmissible spongiform encephalopathies)
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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