Award details

Immune inductor and effector sites in the upper airways of cattle and influence of site of antigen expression on induction of mucosal immunity

Reference	BBS/E/I/00001228
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors	Professor Jayne Hope
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	304,186
Status	Completed
Type	Institute Project
Start date	01/03/2006
End date	03/11/2010
Duration	56 months

Abstract

This project aims to exploit recent advances in the manipulation of the genome of negative-stranded viruses, culture techniques for well-differentiated, bovine airway epithelial cells and characterisation of bovine dendritic cells to: (i). identify the anatomic location and functional potential of bovine nasopharyngeal immune inductor and effector sites; (ii) identify antigen-presenting cells in bovine upper airway tissues; (iii) determine if targeting foreign antigens to different sites within polarised airway epithelial cells influences the induction of mucosal immunity. The information generated from this project will be critical in establishing the value of attenuated virus vectors expressing foreign antigens for the induction of mucosal immunity in cattle, the identify of antigen-presenting cells in the upper airways of cattle and the type of construct most appropriate for stimulating mucosal immunity. This will allow a more targeted approach to the development of intranasal vaccines that will be of broad relevance for a variety of bovine pathogens.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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