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Do post receptor binding events decide the fate of mycobacteria in bovine macrophages?

Reference	BBS/E/I/00001226
Principal Investigator / Supervisor	Professor Tracey Coffey
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	138,922
Status	Completed
Type	Institute Project
Start date	26/06/2006
End date	25/06/2009
Duration	36 months

Abstract

This project aims to address the following: (1) Does the mycobacterial-species specific response of bovine alveolar macrophages and virulence of M.bovis relate to usage of particular pattern recognition receptors (PRR) on the alveolar macrophage surface? (2) Which AlvMa signalling pathways are activated by M.bovis, BCG and Mltuberculosis? (3) Can the differing pathogenicities and virulence of M.bovis, BCG and M.tuberculosis be forecasted by the point at which the MAPK pathway is blocked? - analysis at the protein level. (4) Use of inhibitors to further analyse production of CXCL8, TNF and NO by AlvMa infected with M.bovis, BCG and M.tuberculosis. (5) Using siRNA to confirm roles of different pathways in the AlvMa activation by M.bovis, BCG or M.tuberculosis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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