Award details

Antigen presenting cell populations in cattle

Reference	BBS/E/I/00001211
Principal Investigator / Supervisor	Professor Jayne Hope
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,285,373
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	30/06/2009
Duration	51 months

Abstract

Dendritic cells are the pivotal cell for the initiation and control of immune responses. This class of antigen presenting cell (APC) is essential for the initiation of adaptive immune responses in immunologically naïve animals. They also interact with and stimulate innate responses and link adaptive and innate immunity. The majority of studies of dendritic cells in humans or mouse models involve the culture of precursors. This process is known to affect the function of the cells, which although extremely useful do not precisely mimic cells in vivo. Surgical cannulation of ruminants is a means whereby ex vivo dendritic cells can be isolated from afferent lymphatics draining the skin, and in some cases mucosa, for in vitro and in vivo studies. This technique provides a means of investigating the function of dendritic cells and dendritic cell sub-sets in the context of cattle diseases in experiments that study infection and immunity in the natural host. Previous studies have shown subsets of ex vivo bovine dendritic cells have different functional properties. This project will focus on the characterisation of the biology of dendritic cells and the molecular basis for how they influence responses to pathogens, including Mycobacterium bovis and foot and mouth disease virus, and initiate and control adaptive T cell responses.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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