Award details

Development of marker vaccines and diagnostic tests, and improvement of epidemiological knowledge to facilitate control rinderpest and PPR viruses

Reference	BBS/E/I/00001208
Principal Investigator / Supervisor	Dr Linda Dixon
Co-Investigators / Co-Supervisors	Professor Thomas Barrett
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	66,483
Status	Completed
Type	Institute Project
Start date	01/01/2005
End date	31/12/2009
Duration	60 months

Abstract

Rinderpest (RP) and peste des petits ruminants (PPR) control is considered a priority in the countries where these diseases are endemic (Africa, Middle East and West Asia). Because of their high mortality and high morbidity rates, RP and PPR are dreaded animal diseases included in the list A of the Office International des Epizooties, list of dangerous animal pathogens where extremely contagious animal diseases of high economic importance are grouped. Effective control of RP and PPR by vaccination, through international funding, mainly by the EU, contributes to increasing and sustaining livestock and ensures world food security. In the present proposal, the first objective is to develop marker vaccines capable of preventing RP and PPR infections and also companion tests to differentiate between infected and vaccinated animals. This differentiation is of major importance for eradication programmes because it would allow more precise targeting of vaccination while serosurveillance of the disease could be maintained through the use of companion diagnostic tests. This would allow for a quicker lifting of control measures. Through reverse genetics technology it is also aimed to improve the quality and the safety of these marker vaccines derived from current attenuated strains. Another objective of the proposal is to use improved epidemiological information systems for a better analysis of the current situation for rinderpest and PPR and for predicting the impact of vaccination strategies on the control of the two diseases. Thus the expected outputs from this proposal will give additional support to some existing EU developing country programmes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search