Award details

Prion therapeutics from traditional Chinese herbs

Reference	BBS/E/I/00001203
Principal Investigator / Supervisor	Dr Andrew Gill
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	3,047
Status	Completed
Type	Institute Project
Start date	01/08/2004
End date	31/07/2007
Duration	36 months

Abstract

In this proposal two parallel and highly interactive programmes are proposed. In the screening programme, further optimisation and validation of the test platform as a primary screening tool is required. Also a series of secondary screening techniques based on Western blotting, conformational dependant immunoassay, ligand bind assay, PrP conversion assay and cell culture study are proposed to further validate the ELISA-based primary screening technique and investigate the mode of drug action of the hits found in herbal extracts. At the same time, the chemistry programme will focus on the fractionation and separation to identify the active ingredients in the herbal extract identified through the primary and secondary screening. Efforts will be made to broaden the selection of the herbs from traditional herbs to rare herbal species, to investigate the extraction and separation chemistry, and to chemically synthesise the active compounds in order to speed up the identification of lead compounds.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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