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Influence of neuroendocrine stress hormones on the carriage and virulence of zoonotic bacterial pathogens in farm animals

Reference	BBS/E/I/00001195
Principal Investigator / Supervisor	Professor Mark Stevens
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	249,908
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	31/10/2010
Duration	67 months

Abstract

The potential for host and foodborne neurochemicals to alter the outcome of bacterial infections has far reaching implications for animal welfare and public health and merits urgent investigation. We propose to: 1) quantify the effect of NE and tyramine on E.coli O157:H7- and S.typhimurium-induced enteritis, adherence and invasion in target food-producing animals; 2) assess whether adrenergic receptor antagonists reduce EHEC- and S.typhimurium-induced enteritis and colonisation; 3) assess the relative importance of hormone/antagonists signalling to the pathogen and to host cells in these events; 4) identify NE- and tyramine-responsive genes of E.coli O157:H7 and S.typhimurium; and 5) identify bacterial genes involved in hormone sensing and signal transduction.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, Animal Welfare, Microbial Food Safety, Microbiology, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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