Award details

Characterisation of the molecular basis of systemic salmonellosis in calves

Reference	BBS/E/I/00001179
Principal Investigator / Supervisor	Professor Mark Stevens
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	146,214
Status	Completed
Type	Institute Project
Start date	01/06/2005
End date	31/05/2008
Duration	36 months

Abstract

The objectives are to further characterise the mechanisms of systemic translocation of Salmonella at time points following oral inoculation of calves; to generate a signature-tagged transposon bank for Salmonella enterica serovar Dublin and select mutants proficient in systemic spread; to select tagged mutants containing transposon insertions in selected genes; to screen selected tagged mutants of serovars Dublin and Typhimurium within bovine tissues and efferent lymphatics to determine whether distinct virulence loci contribute to systemic translocation in calves; to construct defined mutations in genes important for systemic salmonellosis, and confirm their role in calves by trans-complementation studies.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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