Award details

Initiation and maintenance of bluetongue and African horse sickness vector colonies of Culicoides midges

Reference	BBS/E/I/00001146
Principal Investigator / Supervisor	Professor Philip Mellor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,314,243
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	30/06/2009
Duration	75 months

Abstract

African horse sickness and bluetongue virus are transmitted between their respective mammalian hosts by vector species of biting midge. Susceptibility of the midges to oral infection and transmission are genetically heritable traits. This means that even within a vector species certain individuals and populations will be competent to become infected and transmit virus while others will not. The barriers to infection and transmission are usually manifested at the level of the gut wall where some individuals will have infection barriers, some will have dissemination barriers and some will have no barriers. Objectives: a) to set up and maintain vector colonies of midges in the new insectaries at IAH-Pirbright for work on competence studies, capacity studies, environmental change studies and modelling studies; b) by selective breeding, to set up and maintain daughter colonies of vector midges with defined rates of oral susceptibility (infection barrier-free or reduced) and transmission (dissemination barrier-free or reduced) to enhance their value as research tools in carrying out the work set out in objective a); c) to identify the molecular basis of the infection and dissemination barriers.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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