Award details

Comparative proteomics of the Apicomplexa: evolutionary perspectives and functional analyses of invasion organelles

Reference	BBS/E/I/00001129
Principal Investigator / Supervisor	Professor Fiona Tomley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	163,773
Status	Completed
Type	Institute Project
Start date	01/09/2004
End date	29/02/2008
Duration	42 months

Abstract

Apicomplexans are the most important parasites of man and livestock. The proposal integrates four research teams with complementary skills in a fundamental study to a) Overview the biomolecular organisation and molecular evolution of apicomplexans through comparative proteomics of purified invasive stages of Cryptosporidium, Eimeria, Plasmodium and Toxoplasma. b) Analyse the proteomes of secretory organelles and with carefully selected gene knockout, protein tagging,/localisation, and protein co-precipitation studies further elucidate the roles of these organelles in host cell recognition and invasion. The data will be of fundamental and broad scientific value and provide a rational foundation for the development of new therapeutic targets.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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