Award details

Understanding FMDV immunology and transmission biology to improve vaccines and vaccination strategies

Reference	BBS/E/I/00001127
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors	Dr Paul Barnett, Professor Shirley Ellis, Professor Jean-Francois Valarcher
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,403,102
Status	Completed
Type	Institute Project
Start date	15/11/2004
End date	28/02/2011
Duration	76 months

Abstract

The proposed research programme will improve the understanding of FMDV transmission in cattle, by carrying out quantitative virological studies that simulate field transmission of FMDV to naive and vaccinated animals. These parameter measurements will be incorporated into mathematical models designed to optimise emergency vaccination programmes. Local and systemic antibody and T cell-mediated immune responses will also be studied, to identify immunological correlates of protection in FMDV-recovered and vaccinated cattle. Finally, we will investigate FMDV vaccine/adjuvant combinations and immunisation regimes to generate strong systemic and local immunity in mice and test promising candidates in cattle.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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