Award details

Understanding FMDV immunology and transmission biology to improve vaccines and vaccination strategies

ReferenceBBS/E/I/00001127
Principal Investigator / Supervisor Professor Bryan Charleston
Co-Investigators /
Co-Supervisors
Dr Paul Barnett, Professor Shirley Ellis, Professor Jean-Francois Valarcher
Institution The Pirbright Institute
DepartmentThe Pirbright Institute Department
Funding typeResearch
Value (£) 1,403,102
StatusCompleted
TypeInstitute Project
Start date 15/11/2004
End date 28/02/2011
Duration76 months

Abstract

The proposed research programme will improve the understanding of FMDV transmission in cattle, by carrying out quantitative virological studies that simulate field transmission of FMDV to naive and vaccinated animals. These parameter measurements will be incorporated into mathematical models designed to optimise emergency vaccination programmes. Local and systemic antibody and T cell-mediated immune responses will also be studied, to identify immunological correlates of protection in FMDV-recovered and vaccinated cattle. Finally, we will investigate FMDV vaccine/adjuvant combinations and immunisation regimes to generate strong systemic and local immunity in mice and test promising candidates in cattle.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsAnimal Health, Immunology, Microbiology
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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