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Investigation of differentially-regulated surface antigens in Eimeria tenella

Reference	BBS/E/I/00001125
Principal Investigator / Supervisor	Professor Fiona Tomley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	71,831
Status	Completed
Type	Institute Project
Start date	18/10/2004
End date	17/10/2007
Duration	36 months

Abstract

Little is known about expression of surface antigens (SAGs) in coccidian parasites. From >14,000 Eimeria tenella ESTs we identified 37 genes that code for related, antigenically variant SAGs and showed experimentally that these are developmentally-regulated, GPI-linked surface proteins. We now propose to analyse the entire E. tenella SAG repertoire, which may include up to 250 different variants. We will investigate the genetic organisation, stage-regulation and differential expression of SAGs during the entire parasite life-cycle and determine whether E. tenella operates a model of antigenic switching or one of co-expression of multiple variants. We will also explore the potential role(s) that EtSAGs play in host-parasite interactions.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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