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An investigation of TSE resistance mechanisms by genetic analysis of PrP binding protein genes
Reference
BBS/E/I/00001124
Principal Investigator / Supervisor
Dr Wilfred Goldmann
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
46,288
Status
Completed
Type
Institute Project
Start date
01/10/2004
End date
30/09/2007
Duration
36 months
Abstract
The PrP protein allotypes are crucial modulators of TSE pathogenesis. Amino acid changes in PrP can mean the difference between susceptibility and resistance but the mechanism through which these effects are enacted is not understood. PrP-binding protein (PrPbp) genes, ie. NCAM or laminin receptor are prime candidates to explore the causal relationship between PrP alleles and phenotypes such as neuronal cell death. We propose to investigate PrPbp¿s in our well-understood sheep scrapie models, by initiating an analysis of their gene sequences, polymorphisms and expression patterns in scrapie-relevant tissues. Co-immunoprecipitations will provide detailed analysis of the molecular interaction between allotypes of PrP and its protein ligands.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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