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Award details
Dynamics, selection and pathogenicity in avian influenza: from individual to population
Reference
BBS/E/I/00001121
Principal Investigator / Supervisor
Professor Munir Iqbal
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
282,971
Status
Completed
Type
Institute Project
Start date
14/11/2004
End date
13/12/2009
Duration
61 months
Abstract
Avian influenza poses a serious disease threat to animal and human populations, and provides an unusual opportunity to synthesize ecological and evolutionary pathogen dynamics. We shall use experimental infections, phylogenetics and mathematical modelling to explore the dynamics and evolution of low (LPAI) and high (HPAI) pathogenicity influenza infections in chickens, based on viral isolates from field outbreaks of HPAI. We shall clarify: (i) the dynamics of LPAI and HPAI infection and host immunity in naïve and previously HPAI-infected birds; (ii) evolutionary changes in the viral haemagglutinin molecule which determine the adaptation of LPAI to chickens and its transition to HPAI; (iii) the transmission dynamics of LPAI and HPAI infection at different scales.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Animal Health, Immunology, Microbiology, Systems Biology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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