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The mechanisms of virus-induced immunosuppression in poultry - the circovirus chicken anaemia virus as a model system

Reference	BBS/E/I/00001112
Principal Investigator / Supervisor	Professor Peter Kaiser
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	84,659
Status	Completed
Type	Institute Project
Start date	24/05/2004
End date	23/05/2007
Duration	36 months

Abstract

Chicken anaemia virus (CAV) is an immunosuppressive circovirus of increasing prevalence, resulting in economic loss to the poultry industry, and exacerbating the effects of other pathogens. The interactions of CAV with its host will be investigated by profiling the host transcriptome following infection in vitro and in vivo. A collaboration between IAH, QUB and RI will exploit a panel of cytokine reagents developed at IAH and a chicken immune-associated microarray developed at RI together with targeted mutants of the three viral genes to be developed at QUB. A co-infection model with Marek¿s Disease Virus will investigate how CAV interacts with other pathogens. Structure/function analysis of CAV genes will determine its pathogenic and immunosuppressive mechanisms and as such will develop CAV as a model for circovirus infections in other species, including mammals.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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