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Changes in the host transcriptome during morbillivirus infection as determinants of virulence and host specificity

Reference	BBS/E/I/00001088
Principal Investigator / Supervisor	Dr Michael Baron
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	35,062
Status	Completed
Type	Institute Project
Start date	15/04/2004
End date	14/05/2008
Duration	49 months

Abstract

The morbilliviruses are negative-strand RNA viruses which cause disease in a variety of hosts; members include measles virus (MV) of humans and rinderpest virus (RPV) of cattle. Although the morbilliviruses are restricted in the host range in which they cause disease, they all seem able to infect most mammalian species at least subclinically. Our hypothesis is that it is differences in the host response to infection that leads to differences in the observed outcomes, and therefore the host-range restriction of the diseases caused by these viruses. We will study the effects on the host transcriptome of infection by virulent RPV using a bovine microarray, and compare this with the effects of infection by avirulent RPV or virulent MV.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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