Award details

Protective immune responses to FMDV in cattle

Reference	BBS/E/I/00001086
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,547,756
Status	Completed
Type	Institute Project
Start date	01/11/2003
End date	30/06/2009
Duration	68 months

Abstract

The focus of this programme of work is to understand the long-term protective memory response to FMDV, and so provide a platform to investigate vaccine candidates. Very little is known about the FMDV MHC class I and II epitopes recognised by T cells in ruminants. The search for these epitopes will reveal which FMDV proteins are important for stimulating cell mediated responses and underpin the development of MHC tetramer technology to study FMDV. The development of MHC tetramers will allow virus specific T cells to be detected within complex cellular populations, and can be used to monitor the magnitude, specificity and duration of T-cell responses during infection and vaccination. Tetramers will also be key to understanding if persistence results from a failure in cell mediated responses to FMDV and whether new generation vaccines can induce the correct populations of T cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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