Award details

The role of cytoskeleton in ASFV egress

Reference	BBS/E/I/00001080
Principal Investigator / Supervisor	Dr Paul Monaghan
Co-Investigators / Co-Supervisors	Professor Tom Wileman
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,572
Status	Completed
Type	Institute Project
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

African Swine Fever virus (ASFV) causes a fatal hemorrhagic disease of domestic pigs. At present there are no cures or vaccines for ASFV, and the spread of the virus is controlled by slaughter. We are studying the intracellular processes that control the assembly and egress of ASF virus, and argue that this information will allow us to design defective viruses that can be used as vaccines to control outbreaks of ASF virus. Virus assembly takes place in specialised structures called viral factories located next to the nucleus. This project will use cell biological and bioimaging assays to determine how viruses leave the factory and reach the cell surface. The project will focus on the use of the cytoskeleton and associated molecular motors by ASFV.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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