Award details

BBSRC Studentship: Examining the protective, antigenic and "marker" potential of chimeric foot-and-mouth disease virus vaccines

Reference	BBS/E/I/00001079
Principal Investigator / Supervisor	Professor David Paton
Co-Investigators / Co-Supervisors	Dr Paul Barnett
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	2,166
Status	Completed
Type	Institute Project
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

To evaluate the protective potential of pre-constructed FMD marker vaccines using chemically inactivated FMD chimera viruses containing replacement FMDV or another foreign sequence in the immunodominant and antigenically important linear site of the structural protein VP1 (G-H loop region). To develop an assay method for evaluating the potential of positively and negatively discriminating the polyclonal antibody responses of such chimera marker vaccines with that elicited by the natural capsid structure. To compare the antigenic spectrum of these chimera marker vaccines with that of the natural FMDV capsid structure normally used in a conventional vaccine. To establish the potency of these chimera marker vaccines and compare with that of the natural FMDV capsid structure normally used in a conventional vaccine.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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