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Biochemical processing in the expression of extra-cytoplasmic proteins in Streptococci and its relation to virulence

Reference	BBS/E/I/00001075
Principal Investigator / Supervisor	Dr Andrew Gill
Co-Investigators / Co-Supervisors	Professor Tracey Coffey, Professor James Leigh, Dr Philip Ward
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	3,161
Status	Completed
Type	Institute Project
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

Bacteria mediate their interactions with the host through molecules located outside the cytoplasm. Translocation of proteins, produced within the cytoplasm, to an extracellular location requires the expression of a combination of specific processing pathways and the presence of recognisable motifs/signals within the protein to be translocated. This project will exploit the recently released genome sequence data from Streptococcus uberis and Streptococcus suis and a recently developed technique for the isolation of mutants within these species to generate isogenic strains that fail to: secrete proteins, anchor proteins in the membrane and anchor proteins in the cell wall. In so doing, this project will identify the genes and gene products underlying these mechanisms in Streptococci. Biochemical and physiological investigation of these mutants will identify components that are secreted and/or anchored via such pathways and their putative role in pathogenesis.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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