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Analysis of proapoptotic markers and cytoskeletal changes in the hippocampus in murine scrapie

Reference	BBS/E/I/00001066
Principal Investigator / Supervisor	Dr Janet Fraser
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	309,882
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/10/2005
Duration	31 months

Abstract

The objectives of this project are: 1) To investigate the upregulation of proapototic markers caspase-3 and Fas throughout the incubation period of disease in the ME7/CV mouse model and compare the results with those obtained in the 87V model. 2) To compare the upregulation of poly(ADP-ribose)polymerase (PARP) one of the proteins cleaved in the caspase pathway, and its relationship with caspase-3 and Fas in both the ME7/CV and 87V/VM model. 3) To develop a FACS analysis technique to measure and compare pro-apoptotic markers and cell types involved in the apoptosis observed in the brains of mice in both the ME7/CV and 87V/VM mouse models. 4) To relate any apoptotic changes observed in both mouse models to the cytoskeletal dysfunction observed in both mouse models.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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