Award details

Using protein biomarkers to identify TSE infection

Reference	BBS/E/I/00001063
Principal Investigator / Supervisor	Dr Janet Fraser
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	82,599
Status	Completed
Type	Institute Project
Start date	01/07/2003
End date	30/06/2004
Duration	12 months

Abstract

This proposal aims to utilise novel technology to identify protein biomarkers specific to TSE diseases. SELDI (surface-enhanced laser desorption/ionisation) is a technique developed by Ciphergen Biosystems which utilises a variety of surface chemistries to capture proteins of interest. The ProteinChip System provides a mass spectrum of a number of proteins which can provide a fingerprint pattern of disease. This strategy could provide significant advantages over currently available tests, not only to identify clinical disease, but also to detect preclinical changes. This feasibility study will consolidate and extend our successful pilot project by identifying the major protein biomarkers in murine TSE, and test the diagnostic potential of this novel system in a range of TSE infected tissues taken initially from established murine scrapie models. Samples will be prepared at IAH Edinburgh, and tested in the Functional Genomics Unit in Moredun Research Institute. If the study is successful we will seek funding for a dedicated cat 3 Ciphergen System in order to be able to examine BSE derived and human tissues.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search