Award details

Role of the G protein in the pathogenesis of respiratory syncytial virus infection

Reference	BBS/E/I/00001062
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	4,464
Status	Completed
Type	Institute Project
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

Bovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease in young calves and is closely related to human (H)RSV, the predominant cause of pneumonia and bronchiolitis in young children. There is a relative lack of direct, detailed information on the pathogenesis of RSV infections at mucosal surfaces. Furthermore the role of the attachment G protein in the pathogenesis of RSV infections has not been clearly defined. In this project, the relative contributions of virus-induced cytopathology and of pro-inflammatory cytokines in the pathogenesis of RSV will be investigated by analysing the interaction of wild-type and mutant BRSV, which contain mutations in various regions of the G protein, with well-differentiated bovine ciliated airway epithelial cell (BAEC) cultures and bovine alveolar macrophages. In addition, the replication of rVV expressing mutant forms of the HRSV G protein will be compared in the lungs of mice. The pulmonary inflammatory, cytokine and chemokine response induced by intranasal infection with the rVV will be analysed. The findings from these investigations will help to define the role of different regions of the G protein in the pathogenesis of RSV infection and will increase our understanding of how the balance of the early innate response to a mucosal pathogen influences the outcome of infection.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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