Award details

Immunology and pathogenesis of bovine respiratory infections

Reference	BBS/E/I/00001052
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	37,515
Status	Completed
Type	Institute Project
Start date	01/11/2003
End date	31/03/2007
Duration	41 months

Abstract

The sustainable, long-term control of infectious diseases of cattle will depend upon vaccination and/or breeding for disease resistance. The application of these measures will minimise or reduce reliance on the use of antimicrobial compounds that are predominantly used in young cattle to control respiratory and enteric diseases. However, it has been difficult to develop vaccines against a number of important respiratory pathogens. Furthermore, vaccination against some respiratory pathogens has resulted in enhanced disease. An understanding of the interactions between pathogens, the respiratory mucosa and the innate and acquired immune response will lead to the development of measures that will control calf respiratory disease. In this project, bovine respiratory syncytial virus (BRSV), which is a major cause of pneumonia in young calves will be used to investigate:1) components of BRSV that contribute to the pathogenesis of disease 2) components of the host response that contribute to the pathogenesis of disease 3) how RSV influences the development and duration of acquired immunity. These studies may lead to the development of improved strategies that will reduce the incidence of respiratory disease due to RS viruses, either through selective breeding for disease resistance or through the development of live attenuated BRSV vaccines. Furthermore the findings from these studies may provide information for the development of control measures against other bovine pathogens. This will lead to improvements in calf health and welfare and reduce the use of antimicrobial compounds.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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