Award details

Studies on avian infectious bronchitis for safe, technologically advanced vaccines for long-tern sustainable control

Reference	BBS/E/I/00001050
Principal Investigator / Supervisor	Professor David Cavanagh
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	9,233
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

Infectious bronchitis (IB) is the major respiratory disease of the domestic fowl amongst the nearly one billion chickens present annually in the UK. Manipulation of the IB virus (IBV) genome has the potential of producing better vaccines in a rational and timely manner: genetically stable i.e. not reverting to virulence; less interference between two IB vaccines given concurrently; genetically marked to aid diagnosis and epidemiological studies. The main objective of this project is to assess the effects on pathogenicity of specific, well-defined alterations to the genes encoding the surface spike protein and the four nonstructural (accessory) proteins 3a, 3b, 5a and 5b. This will also increase our understanding of the role of these proteins in the disease process. To date no function has been assigned to the accessory proteins of IBV or any other coronavirus. We shall answer these questions using our infectious cDNA clone of the 27,600 nucleotide RNA genome of IBV. We have cloned this cDNA in the genome of vaccinia virus, enabling us to use transient dominant selection to modify the IBV genes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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