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The replication of avian influenza viruses in cells of avian and mammalian origin

Reference	BBS/E/I/00001025
Principal Investigator / Supervisor	Professor Munir Iqbal
Co-Investigators / Co-Supervisors	Professor Fiona Tomley
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	763,611
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	30/06/2009
Duration	75 months

Abstract

The spread of influenza virus isolated in one species to another is defined as host range. Virus host range is a multigenic trait. Almost all of the genes have been clearly linked with restriction of the replication of avian influenza viruses in mammalian infection models. In tissue culture models of infection one gene that very frequently is linked with host range is the PB2 polypeptide gene. Out previous work, carried out in collaboration Dr W. Barclay (University of Reading), identified a region of PB2 in a well-established pair of very early avian influenza virus isolates that controlled infection in mouse cells. Work will be carried out to define more multigenic traits of host cell restriction of replication in bovine and human cells from viruses that belong to the current Eurasian lineage of avian influenza viruses. This will be done through the use of traditional reassortant viruses as well as recombinant viruses generated through reverse genetic techniques.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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