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Interactions of Bovine viral diarrhoea virus with the host cell

Reference	BBS/E/I/00001024
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	718,138
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

Our work is to model on how virus persists in foetal tissue. Our model uses infection of early passage tissue culture cells that show a wide range of innate immune responses with BVDV. This programme of experiments is directed towards determining the roles of individual virus polypeptides in establishing persistent infection, and dissecting the responses of the cell to infection with virus having such an unusual replication strategy. Work will be directed to understanding how the virus avoids the response of cells to dsRNA. We postulate that the glycoproteins of the virus may be able to interfere, in some way, with the initiation of the signalling cascade that leads to interferon stimulated gene expression. We have developed insect cell-based systems for the expression of secreted forms of each of the glycoproteins and these will be utilized to test this hypothesis. In addition, influence of other virus polypeptides in this and other cellular processes will be investigated.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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