Award details

Pathogenesis, excretion, persistence and transmission of foot-and-mouth disease

Reference	BBS/E/I/00001023
Principal Investigator / Supervisor	Dr Zhidong Zhang
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	40,523
Status	Completed
Type	Institute Project
Start date	01/06/2003
End date	31/05/2006
Duration	36 months

Abstract

Quantitative analysis of kinetics of FMDV replication, excretion, transmission and clearance during acute and persistent infection in cattle, sheep and pigs will provide improved data for models of disease spread, for giving veterinary advice and for improved risk assessment. Molecular characterisation of FMDV genomes amongst different isolates in relation to their acute virulence and ability to establish persistent infection in susceptible livestock will provide insight into the relationship between genetic make-up and biological properties and will potentially provide a basis for early predictions of severity of a new outbreak or for improved and rapid control of FMD. Identification and quantitative analysis of host factors responding to FMDV infection, especially virus/host interactions involved in pathogenesis of disease and in establishment or clearance of infection may provide a rational basis for development of improved vaccines or drugs preventing or curing carrier animals. Characterisation of bovine epithelial cells persistently harbouring FMDV. Such a ex vivo model will make it possible to further define cellular factors and mechanism involved in the regulation of virus expression, persistence and clearance in target cells and may assist in defining selective approaches to control FMDV in persistently infected animals.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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