Award details

Salmonella pathogenesis in cattle and pigs

Reference	BBS/E/I/00001021
Principal Investigator / Supervisor	Professor Mark Stevens
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	97,355
Status	Completed
Type	Institute Project
Start date	01/07/2002
End date	30/09/2006
Duration	51 months

Abstract

Salmonellosis is now one of the most important bacterial diseases of man and animals in the U.K. and has important implications for human and animal health and welfare. The aim of this study is to characterise further the virulence factors influencing Salmonella pathogenesis and the host response to infection in cattle and pigs. The unique facilities of IAH, Compton will be exploited to study natural host/pathogen interactions at the molecular level. Cattle will be infected orally with wild type and mutant strains of S.typhimiurium and the faecal shedding of such strains quantified. Factors influencing intestinal colonisation will be identified and assessed for incorporation into a vaccine. Bovine and porcine ligated ileal loops will be infected with wild-type and defined mutant strains of different Salmonella serotypes The effect of infection on the host will be determined with respect to Salmonella-induced enteropathogenic and inflammatory responses. The role of specific genes in influencing such responses will be characterised. This approach will provide insight into the molecular basis of Salmonella pathogenesis, information which is essential for the design of effective and sustainable control measures and reduced reliance on the use of antibiotics. The research meets DEFRA policy requirements on food safety and animal health and welfare. The strategic aims are to safeguard food safety, reduce the impact of bacterial disease, develop effective vaccines that cross protect against all Salmonella serotypes and reduce the dependance on antibiotics which may lead to the emergence of more antibiotic resistant strains.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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