Award details

Identification and shaping of protective T cell responses to bovine viral diarrhoea virus

Reference	BBS/E/I/00001020
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	988,560
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2007
Duration	48 months

Abstract

1. To complete the studies to define the CD4+ T cell epitopes in the E2 and NS3 proteins and to determine the extent to which they vary between different virus isolates. 2. To identify the cytokines produced by the BVDV-specific CD4+ T cells and their ability to provide help for antibody production. 3. To determine the he capacity of virus-specific CD4+ T cells to provide help for antibody production. 4. To identify proteins and epitopes recognised by BVDV-specific CD8+ T cells. 5. To determine whether additional BVDV structural proteins (E1, Erns and P7) are required for assembly and secretion of E2 in an immunogenic form from transfected cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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