Award details

Avipox Viromics

Reference	BBS/E/I/00001019
Principal Investigator / Supervisor	Professor Michael Skinner
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	754,046
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/10/2005
Duration	31 months

Abstract

Although we intend to continue targeted study of specific candidate immunomodulators (IL-18bp and, should appropriate opportunities arise, the chemokine-like proteins), the major aim is to develop broad scale viromic approaches using genetics and biochemistry or cell biology. A primary target of the viromics is to develop genetic approaches to identify factors involved in resistance to type I interferon. In one approach, we will screen a bank of pan-genome knockouts for loss of trans-acting resistance to exogenous type I interferon. In a complementary approach, we will screen an expression library for complementation of a defect in resistance to type I interferon. Establishing the mutant bank and expression library will be a major part of the programme but will provide resources available for identification of genes involved in functions other than resistance to type I interferon. Work will continue on the yeast-2-hybrid analysis of interactions between selected FPV proteins and host proteins as well as between a random library of all FPV proteins. In particular, work will address the validity and role of interactions identified.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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