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Role of RNA-protein interactions in picornavirus replication
Reference
BBS/E/I/00001017
Principal Investigator / Supervisor
Professor Graham Belsham
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
628,498
Status
Completed
Type
Institute Project
Start date
01/04/2003
End date
31/10/2005
Duration
31 months
Abstract
1) To analyse the role of FMDV L and 3C proteases and enterovirus 2A protease on cap-dependent and IRES-dependent translation initiation. 2) To determine sites in translation initiation factor eIF4GI and eIF4GII cleaved by FMDV and enterovirus proteases within cells. 3) To determine role of residue 20 of the SVDV 2A protease in virus growth and pathogenicity. 4) To determine properties of the novel teschovirus IRES in vitro and within cells.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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