Award details

Determinants of virulence and host-specificity in morbilliviruses

Reference	BBS/E/I/00001014
Principal Investigator / Supervisor	Dr Michael Baron
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	735,814
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	30/06/2009
Duration	75 months

Abstract

Rinderpest virus (RPV) causes an economically highly important disease of cattle and is currently the target of a worldwide eradication campaign, just as its nearest relative, human Measles virus (MV), is the target of a similar eradication campaign. We are measuring the innate immune responses to infection by RPV, and determining if these vary with host species and virus strain. Using recombinant viruses, we will seek to identify the viral proteins that are responsible for any observed differences in host response. This work complements other current projects looking directly at interactions of RPV proteins with host cell proteins, mutations that affect viral virulence, and the roles of the viral non-structural proteins in the virus life-cycle. We are also seeking to identify the viral receptor(s) for RPV, and particularly if different receptors are used by different strains of the virus; we have already shown that the viral attachment protein is responsible for some of the tissue-specificity of different RPV strains.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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